Monday-27 August

Registration open 8 a.m.  – Coffee for early birds
Conference start 9 a.m.

Monika Sester, Saarland University: Welcome

Modelling Biological Barriers: non-animal models for facilitating clinical translation; epi-/ endothelial barriers: lung, skin, GI, BBB; non-cellular barriers: mucus and surfactant; modelling diseased barriers: infection and inflammation; microfluidics and bioprinting

Heike Walles/ TERM, University Hospital Würzburg:
Complex human co-culture tissue models and their application in drug development

Pankaj Karande/ Rensselaer: Fabrication of a full-thickness vascularized human skin using 3D bioprinting

Skin Barrier

Maike Windbergs/ University of Frankfurt: The human skin in heathy and diseased state – in vitro models and imaging approaches
* Guest Speaker of the Galenus Privatstiftung *

Ciarán Fisher, Certara: Modelling distribution using physiologically-based pharmacokinetic models

P. Volz, FU Berlin: Cluster Fluorescence Lifetime Imaging as a tool to detect oxidative stress and visualize nanocarriers interacting with the skin

D. Kottke, Heinrich-Heine University Dusseldorf: ex vivo permeation studies to facilitate the development of a buccal child-appropriate dosage form by using lidocaine

M. Sacha, Across Barriers : Snake shed skin as in vitro percutaneous absorption model for testing transdermal drugs

C. Nunes Lemos, Universidade de São Paulo: Neurotensin-loaded silk fibroin films associated with iontophoresis as a wound dressing approach

J.  R. Brewer, University of Southern Denmark: The molecular pathway through human skin

Lung Barrier

Kwang-Jin Kim/ University of Southern California: Electrophysiological approaches to characterize epi/endothelial barrier properties

Katharina Ribbek/ MIT: Microbial Interactions and Transport in the Mucus Barrier
* Guest Speaker of the Galenus Privatstiftung *

R. Abu-Dahab, University of Jordan: Development of a co-culture in vitro model simulating Cystic Fibrosis lung infected with Pseudomonas aeruginosa

Maximiliano Gutierrez/ Francis Crick Institute: Crossing barriers to improve tuberculosis treatment

D. Kessie, University of Würzburg: Characterization of Bordetella pertussis virulence mechanisms using engineered human airway models

Josué Sznitman/ Israel Institute of Technology: Advanced airway-on-chip platforms: bridging in vitro and in vivo pulmonary interfaces
* Guest Speaker of the Galenus Privatstiftung *

Nina Hobi/ ARTORG, University of Bern: Organs-on-chip models of the air-blood barrier

Nanomedicine/ Nanotoxicology

Tejal Desai/ UCSF: Nanostructured Materials for Therapeutic Delivery and Immunomodulation

F. Leonard, Houston Methodist Research Institute: Macrophages polarization – emerging target of nanomedicine for inflammatory-related diseases

T. Buerki-Thurnherr, EMPA: Nanoparticle uptake and toxicity assessment in a novel standardized human placental organoid model

J. Bussmann, Leiden Academic Centre for Drug Research: Mechanistic insight into nanoparticle-based drug delivery using the zebrafish embryo model

C. Hempt, EMPA: Advanced in vitro models of the human intestinal barrier – improvements for nanomaterial translocation studies

O.I. Vernaya, Moscow State University: Cryochemical synthesis of controlled release systems based on Ag and Cu nanoparticles, antibacterials and biopolymer matrices

Hamid Ghandehari/ University of Utah: Biological Fate and Toxicity of Dendritic and Silica Nanoconstructs

End of Conference: 7 p.m.

All attendees of the conference are cordially invited to a reception with food and drinks at Across Barriers at Science Park Saar (5 min walk from the conference site).


A poster exhibition with the contributions of the participants will be present during the whole conference.