Monday-27 August

8:00 Registration open  – coffee and snacks for early birds

9:00 OPENING CEREMONY with SURPRISE PERFORMANCE

Martina Sester, Vice President of Saarland University

Stephan Kolling, State Secretary of Saarland

Claus-Michael Lehr: Brief Introduction to HIPS – Helmholtz Institute for Pharmaceutical Research Saarland and HZI – Helmholtz Center for Infection Research

Surprise Performance

Modelling Biological Barriers

10:00 Heike Walles/ Department Tissue Engineering & Regenerative Medicine (TERM), University Hospital Würzburg, Germany: Complex human co-culture tissue models and their application in drug development

10:30 Pankaj Karande/ Rensselaer Polytechnic Institute, USA: Fabrication of a full-thickness vascularized human skin using 3D bioprinting

11:00 to 11:30 coffee break and poster walks

Skin Barrier – Session Chair: Brigitta Loretz

11:30 Maike Windbergs/ University of Frankfurt, Germany: The human skin in heathy and diseased state – in vitro models and imaging approaches
* Guest Speaker of the Galenus Privatstiftung *

12:00 Ciarán Fisher/ Certara, UK: Modelling distribution using physiologically-based pharmacokinetic models

12:15 Pierre Volz/ FU Berlin, Germany: Cluster Fluorescence Lifetime Imaging as a tool to detect oxidative stress and visualize nanocarriers interacting with the skin

12:25 Manuel Sacha/ Across Barriers, Germany : Snake shed skin as in vitro percutaneous absorption model for testing transdermal drugs

12:35 Jonathan  R. Brewer/ University of Southern Denmark: The molecular pathway through human skin

12:50 – 13:50 lunch catering

Lung Barrier – Session Chair: Nicole Schneider-Daum

13:50 Cornelia Sonntag/ Galenus Privatstiftung, Austria

14:00 Katharina Ribbeck/ Massachusetts Institute of Technology, USA: Microbial Interactions and Transport in the Mucus Barrier
* Guest Speaker of the Galenus Privatstiftung *

14:30 Kwang-Jin Kim/ University of Southern California, USA: Electrophysiological approaches to characterize epi/endothelial barrier properties

14:50 Rana Abu-Dahab/ University of Jordan: Development of a co-culture in vitro model simulating Cystic Fibrosis lung infected with Pseudomonas aeruginosa

15:05 Maximiliano Gutierrez/ The Francis Crick Institute, UK: Crossing barriers to improve tuberculosis treatment

15:35 David Kessie/ University of Würzburg, Germany: Characterization of Bordetella pertussis virulence mechanisms using engineered human airway models

15:45 Josué Sznitman/ Israel Institute of Technology: Advanced airway-on-chip platforms: bridging in vitro and in vivo pulmonary interfaces
* Guest Speaker of the Galenus Privatstiftung *

16:15 Nina Hobi/ ARTORG, University of Bern, Switzerland: Organs-on-chip models of the air-blood barrier

16:30 – 17:00 coffee break and poster walks

Nanomedicine/ Nanotoxicology – Session Chair: Cristiane de Souza Carvalho-Wodarz

17:00 Tejal Desai/ University of California, San Francisco, USA: Nanostructured Materials for Therapeutic Delivery and Immunomodulation

17:30 Fransisca Leonard/ Houston Methodist Research Institute, USA: Macrophages polarization – emerging target of nanomedicine for inflammatory-related diseases

17:45 Tina Buerki-Thurnherr/ EMPA – Swiss Federal Laboratories for Materials Science and Technology: Nanoparticle uptake and toxicity assessment in a novel standardized human placental organoid model

18:00 Jeroen Bussmann/ Leiden Academic Centre for Drug Research, The Netherlands: Mechanistic insight into nanoparticle-based drug delivery using the zebrafish embryo model

18:15 Claudia Hempt/ EMPA – Swiss Federal Laboratories for Materials Science and Technology: Advanced in vitro models of the human intestinal barrier – improvements for nanomaterial translocation studies

18:25 Olga I. Vernaya/ Moscow State University, Russia: Cryochemical synthesis of controlled release systems based on Ag and Cu nanoparticles, antibacterials and biopolymer matrices

18:35 Hamid Ghandehari/ University of Utah, USA: Biological Fate and Toxicity of Dendritic and Silica Nanoconstructs

19:05 Adjourn

All attendees of the conference are cordially invited to a reception with food and drinks offered by Across Barriers at Science Park Saar
(5 min walk from the conference site).

A poster exhibition with the contributions of the participants will be present during the whole conference.

Please note: Changes in the schedule are subject to alternations!